Any Pearl Jam fans? There's a few I could select for 'most meaningful'. Indifference comes to mind, but it's not really rock at all. Oceans is another. The whole Ten album is very meaningful to me, its an incredible debut album. This one below is one I will never stop playing.
Good memories of seeing them live a few times. I travelled a bit around north America in my 20s and this band, along with Soundgarden became the go to with the group I was travelling with.